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Born Maria Izadora Ussher Calzado, she was named after the dancer, Isadora Duncan. Her father is choreographer and TV director Lito Calzado and her mother was Irish-Spanish-Filipina, Mary Ann Ussher. Calzado 's brother, Dash Calzado, is a member of Legit Misfitz, a Pinoy rap group.

In the late 1990s, she finished her high school in Miriam College and then completed her undergraduate education in the University of Santo Tomas with a degree in Fine Arts.